Nelson suffered a Vase hangover as Colne claimed their first derby win in five attempts.
The visitors were given a dream start in just the second minute. There appeared to be no danger as Nelson captain John Luker headed clear out on the right, but Keiron Demaine volleyed an absolute cracker from 25 yards across stranded keeper Chris Thompson and into the top left hand corner of the net.
While it was a shock to the system, neither side took a grip, and it was midway through the half before the next real chance came, with Colne keeper Russell Saunders diving well to his left to tip Luke Hargreaves' rasping shot wide of the right hand upright.
Chances continued to be at a premium, and the only other real chance of note in the first period fell to Colne's Matthew Tindall, who drove wide of Thompson's left hand upright just after the half hour.
Colne extended their lead within five minutes of the second half. After some pressure from Nelson, the ball was cleared to the halfway line, and Mark Threlfall outmuscled a Blues defender before powering through and curling a crisp 20 yard effort beyond the despairing Thompson and into the bottom left hand corner.
Within two minutes it was almost three as a lay off to Colne's Demaine saw him curl a low effort just wide of the right hand post.
Nelson were stuggling to gain any momentum, and their task was further hindered when defensive midfielder Darren Wright was shown a straight red for a poor challenge just outside his own box.
And Colne made the home side pay as Threlfall grabbed his third with fifteen minutes remaining, hitting a low shot from the left edge of the area into the bottom left hand corner.
Five minutes later Billy Priestley was unlucky to see a bullet header from a corner go narrowly over the bar, before Nelson launched a late rally - Holt denied by some smart defending when clean through, and Saunders making a brave stop from the onrushing Sam Heap.
But it proved to be too little too late as Colne held on to deservedly grab their first derby win in two years.
